منابع مشابه
Evaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملEvidence Based Medicine: Clinical Trials
Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...
متن کاملSpecifying objectives and outcomes for clinical trials.
THOROUGH DEFINITIONS and descriptions of the objectives and outcomes in clinical trials lead to results that are more readily interpretable and more easily generalisable. Indeed, the failure to prospectively define both objectives and outcomes in sufficient detail, and to describe how these are to be measured, has been a major criticism of some randomised trials. 1 Items 5 and 6 of the CONSORT ...
متن کاملTranslating clinical trials into meaningful outcomes.
Efforts to unravel the complex biology that is necessary to develop new therapies best suited for an individual with cancer are at a crossroads with a strained health care system and an insufficient clinical trial apparatus. The resulting failures have been described as the "valley of death." Progress into the future will require new considerations and the engagement of a broad band of stakehol...
متن کاملStandardising Outcomes in Paediatric Clinical Trials
Whether decisions about the health care of children are made by parents, carers, health practitioners, or children themselves, ideally these decisions will be informed by the results of systematic reviews of previous clinical trials. Unfortunately, drawing on research from the past when making these decisions is not straightforward, even with the advent of systematic reviews, because different ...
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ژورنال
عنوان ژورنال: Neurologic Clinics
سال: 2013
ISSN: 0733-8619
DOI: 10.1016/j.ncl.2013.04.011